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Research 

The Rheumatology Division at the Children's Hospital at Montefiore (CHAM) is a national leader in children’s rheumatologic care and research.  Our research focuses on novel therapies for children with  chronic arthritis and systemic juvenile idiopathic arthritis. We also concentrate on atherosclerosis prevention in pediatric systemic lupus erythematosus and nonpharmacologic treatment of pain in childhood rheumatologic conditions. Our groundbreaking studies have helped to create new therapies that are revolutionizing the treatment of children and adolescents suffering from rheumatologic diseases and disorders. 

We are currently focused on research to:   

Develop a National Registry to Track Outcomes of Pediatric Rheumatologic Diseases

We have the largest registry in the world for pediatric rheumatic diseases, such as juvenile idiopathic arthritis, childhood systemic lupus erythematosus and juvenile dermatomyositis. This registry has led to greater understanding of predictors of good and poor outcomes in these diseases and has consequently helped healthcare workers to better tailor treatments for individual patients.  It has also enabled the collection of long-term safety surveillance data in patients on biologic therapies to better understand the risks of these therapies, such as infections.

Develop Novel Therapeutics

Clinical trials using novel agents in systemic lupus erythematosus and juvenile idiopathic arthritis in children have broadened the pharmacologic armamentarium to treat these diseases in patients who do not respond well enough to or who cannot tolerate treatment with conventional therapies.  

Study the Risk of Cardiovascular Disease in Juvenile Dermatomyositis

CHAM investigators spearheaded the first study of children with juvenile dermatomyositis to look for early evidence of atherosclerosis (hardening of the arteries) before cardiovascular events occur.  This will enable the use of preventive measures in children and adolescents who are at higher risk for heart attacks and stroke.

 

 

 

 

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionARCHIVE: A registry for children with vasculitis: e-entry IRB# 08-04-111E
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorDawn Wahezi, MD
Contact Marija Dionizovik-Dimanovski
(718) 696-2402
Email Contact
Trial DescriptionComparison of menstrual patterns and ovarian reserve in adolescent girls with systemic lupus erythematosus, juvenile idiopathic arthritis, and girls without chronic illness IRB# 2014-3824
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorDawn Wahezi, MD
Contact Marija Dionizovik-Dimanovski
(718) 696-2402
Email Contact
Trial DescriptionEfficacy, Safety And Tolerability Of Tofacitinib For Treatment Of Polyarticular Course Juvenile Idiopathic Arthritis (JIA) In Children And Adolescent Subjects - Click here for more informationIRB# 15-10-199
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorNorman Ilowite, MD
Contact Marija Dionizovik-Dimanovski
(718) 696-2402
Email Contact
Trial DescriptionLong-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic Arthritis - Click here for more informationIRB# 15-10-339
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorNorman Ilowite, MD
Contact Marija Dionizovik-Dimanovski
(718) 741-2456
Email Contact
Trial DescriptionMood disorder and cognitive dysfunction in pediatric lupus IRB# 2000-154
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorChaim Putterman, MD
Contact Tamar Rubinstein, MD
(718) 741-2459
Email Contact
Trial DescriptionObservational Study of Pediatric Rheumatic Diseases: The CARRA Registry - Click here for more informationIRB# 2015-5327
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorYonit Sterba Ruas, MD
Contact Marija Dionizovik-Dimanovski
(718) 696-2402
Email Contact
Trial DescriptionPediatric Lupus Trial of Belimumab Plus Background Standard Therapy (PLUTO) - Click here for more informationOCT12-0166; IRB# 12-07-231
Disease/ConditionArthritis, Lupus and other Rheumatology Conditions
Principal InvestigatorDawn Wahezi, MD
Contact Marija Dionizovik-Dimanovski
(718) 696-2402
Email Contact
View all Clinical Trials