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Research

In conjunction with the Albert Einstein College of Medicine, the Division of Endocrinology and Diabetes at CHAM participates in a wide range of research from basic science to human clinical trials.

CHAM_Pt_Study_Heptulla_2013_06-141_316x210The Division of Endocrinology and
Diabetes—led by Rubina Heptulla, MD, a
nationally-respected researcher and clinician—participates in a wide range of research from basic science to human clinical trials In conjunction with Albert Einstein College of Medicine.

Our research includes conducting trials for newly diagnosed diabetes patients and those living with type 1 or type 2 diabetes, polycystic ovarian syndrome or obesity, as well as screening for relatives of type 1 diabetics and much more. We are currently focused on research to:  

Improve the Quality of Life for Children with Diabetes

Through research using the artificial pancreas and drug therapy, CHAM endocrinologists are working to automate mealtime glucose measurement and insulin delivery, and reduce sugar levels in type 1 diabetics. Patients in the current study have not had to worry about frequent glucose checks, and blood sugars remain under control.

Create Better Outcomes for Girls with Turner Syndrome

As a destination of choice for girls born with Turner syndrome, and their families, CHAM’s experts draw upon the hospital’s vast resources—including infertility treatment, diabetes and thyroid management, and orthopaedic surgery—to treat the many health concerns that these patients encounter. CHAM has also partnered with the Turner Syndrome Foundation to host in-depth educational seminars each year.

Discover Alternative Approaches to Nutritional Counseling

Endocrinologists and nutritionists at CHAM are studying whether nutrition and weight-loss counseling provided in a group setting is equally or more beneficial than a one-on-one approach. Each session offers patients and their parents the opportunity to ask questions and interact with other families, thereby building a lasting network of support and providing an effective means through which lower-income families can achieve their health goals.

Prepare for Diabetes Care During Disaster

By surveying patients in the months after Hurricane Sandy, CHAM endocrinologists determined that patients in lower socioeconomic brackets were equally prepared as those who are more affluent for general disasters and diabetes management. These findings differ from results of an earlier survey conducted in Texas and serve to guide CHAM’s future educational efforts.
Research is a great way to get involved, learn more about diabetes, be more involved in your care and help others. 

You can use the information below to learn more about some of our trials.

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Childrens Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens - Click here for more information08-09-335E
Disease/ConditionOncology (Medical/Hematologic)
Pediatric Hematology/Oncology
Pediatrics
Principal InvestigatorLisa Gennarini, MD
Contact Joyce Brown

Email Contact
Trial DescriptionA Multicenter Single-arm Extension Study to Characterize the Long-term Safety of Cinacalcet Hydrochloride in the Treatment of Secondary Hyperparathyroidism in Pediatric Subjects With Chronic Kidney Disease on Dialysis - Click here for more informationIRB# 20140159
Disease/ConditionDiabetes and Endocrine
Kidney Disease and Transplant
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionA Single-arm, Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD - Click here for more information14-10-545Q-01
Disease/ConditionPediatrics
Pediatric Hematology/Oncology
Hematology
Principal InvestigatorDeepa Manwani, MD
Contact Elodie Benard

Email Contact
Trial DescriptionAn Open Label Study of CM-AT for the Treatment of Children With Autism - Click here for more information15-10-176-01
Disease/ConditionAutism
Psychiatry - Non Cancer
Pediatrics
Principal InvestigatorEric Hollander, MD
Contact Eric Hollander, MD

Email Contact
Trial DescriptionChildhood Asthma Perception Study (CAPS) - Click here for more information2014-3257
Disease/ConditionAllergy & Immunology
Allergy and Immune Disorders
Asthma and other Respiratory Diseases
Pediatrics
Principal InvestigatorJonathan Feldman, PhD
Contact Jonathan Feldman, PhD

Email Contact
Trial DescriptionClinical Assessment Study in Crigler-Najjar Syndrome (LUSTRO) - Click here for more information17-10-18-01
Disease/ConditionGenetics
Genetic Disorders
Pediatrics
Principal InvestigatorNadia Ovchinsky, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionEffectiveness and Safety of Dysport® (abobotulinumtoxinA) in Paediatric Lower Limb Spasticity - Click here for more information17-10-210-01
Disease/ConditionRehabilitation Medicine
Pediatrics
Principal InvestigatorYuxi Chen, MD
Contact Beendu Pujar

Email Contact
Trial DescriptionEntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study) (HFN-LIFE) - Click here for more information16-10-403-01
Disease/ConditionCardiology
Heart and Vascular Disease
Pediatrics
Principal InvestigatorJacqueline Lamour, MD
Contact Chelsie Cornelius

Email Contact
Trial DescriptionLong-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome (SBS) Who Completed TED-C14-006 - Click here for more information16-10-292Q-01
Disease/ConditionPediatrics
Digestive and Intestinal
Principal InvestigatorJohn Thompson, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionLong-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study - Click here for more information16-10-293Q-01
Disease/ConditionPediatrics
Digestive and Intestinal
Principal InvestigatorJohn Thompson, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionLow Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy (COMBINE) - Click here for more information2017-7692
Disease/ConditionPediatrics
Digestive and Intestinal
Principal InvestigatorGitit Tomer, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionNatural History Study of the Development of Type 1 Diabetes - Click here for more informationOCT12-0154; IRB# 12-03-115E
Disease/ConditionDiabetes and Endocrine
Principal InvestigatorRubina Heptulla, MD
Contact Rubina Heptulla, MD
(718) 920-5473
Email Contact
Trial DescriptionPromoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination (PRAGMATIC) - Click here for more information2016-6258
Disease/ConditionAsthma and other Respiratory Diseases
Pediatrics
Principal InvestigatorMarina Reznik, MD
Contact Guadalupe Salazar

Email Contact
Trial DescriptionProtocol For A Research Database For Hematopoietic Stem Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries - Click here for more information2015-5698
Disease/ConditionPediatrics
Hematology
Principal InvestigatorDeepa Manwani, MD
Contact Elodie Benard

Email Contact
Trial DescriptionRare and Cutaneous Non-Hodgkins Lymphoma Registry - Click here for more information06-04-247E
Disease/ConditionPediatrics
Cancer and Genetics
Principal InvestigatorLisa Gennarini, MD
Contact Joyce Brown

Email Contact
Trial DescriptionStudy of Allogeneic EBV-CTLs in EBV-Associated Viremia or Malignancies - Click here for more information16-10-211-01
Disease/ConditionPediatrics
Principal InvestigatorLisa Gennarini, MD
Contact Elodie Benard

Email Contact
Trial DescriptionStudy of Allogeneic EBV-CTLs in EBV-Associated Viremia or Malignancies - Click here for more information16-10-296-01
Disease/ConditionPediatrics
Hematology
Principal InvestigatorLisa Gennarini, MD
Contact Elodie Benard

Email Contact
Trial DescriptionThe Influence of Breakfast on Hormone Responses and Cognitive Performance - Click here for more information2015-5542
Disease/ConditionPediatrics
Principal InvestigatorRubina Heptulla, MD
Contact Liset Estanislao

Email Contact
Trial DescriptionThe Pediatric Diabetes Consortium (PDC): Type 2 Diabetes in Youth Registry IRB# 2015-5480
Disease/ConditionDiabetes and Endocrine
Principal InvestigatorRubina Heptulla, MD
Contact Doreen Johnson-Newell
(718) 920-4664
Email Contact
View all Clinical Trials