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Adolescent Medicine

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Research 

CHAM’s Division of Adolescent Medicine is committed to spearheading research on a wide range of medical and psychosocial problems that adolescents face.

We are currently conducting research on:

Long-Acting Reversible Contraception to Prevent Teen Pregnancy

The teen pregnancy rate in the Bronx is 70 percent higher than in the nation as a whole. To address this, our team has established a long-acting reversible contraception service at CHAM that provides and studies long-acting reversible contraception methods, including dermal implants and intrauterine contraception. We studied the use of effective contraception by adolescent girls for six months and found that intrauterine contraception, the IUD, was significantly less likely to be discontinued at six months compared with the “pill,” “shot,” “patch,” or “ring” methods of hormonal contraception.

We are partnering with several other leading institutions to build a database and further study long-acting reversible contraception (LARC) use in adolescents. We are also currently working on a quality improvement project to improve LARC insertion rates for adolescents.  We are forming interventions to address barriers affecting LARC uptake on the first LARC clinic visit. 

Improving the Health of Patients with HIV/AIDS

The Adolescent AIDS Program (AAP) at CHAM aims to improve local, national and global responses to HIV/AIDS among youth through innovative medical care, research, training, advocacy and community mobilization. We offer a variety of research studies to patients—ranging from the latest in HIV medication clinical trials to studies gathering information on the medical and psychosocial issues for youth living with or at risk for HIV.

One of 14 locations across the United States chosen to participate in the National Institutes of Health (NIH)–funded Adolescent Trials Network for HIV/AIDS interventions, our program recently expanded its research opportunities to HIV-negative youth with studies on HIV prevention and testing.

Improving the Health of Obese Teens

CHAM adolescent medicine physicians work with severely obese teens and their families through the B’N Fit clinical service to help with weight management and healthy lifestyle behaviors. Evaluation of the B’N Fit participants, after six months, indicated significant decreases in rates of weight gain and increases in fruit and vegetable consumption. Participants also increased their level of vigorous physical activity.

We are currently evaluating a school-based intervention to promote resilience and prevent diabetes for youth attending PS/MS-95. B’N Fit POWER is a wellness program that integrates existing school wellness promotion activities, the Montefiore School Health Program (MSHP) – a network of school-based health clinics, and the Mosholu Montefiore Community Center (MMCC) – a network of afterschool programming, to promote health and build on the resilience of the adolescents. The translation of a traditional clinical-based weight-loss intervention to adapting and implementing such an intervention in a real-world school setting is more relevant and sustainable for advancing a culture of health and promoting diabetes risk reduction in Bronx youth.

Improving Resident Education in Pediatric and Adolescent Gynecology

In collaboration with educators at the North American Society for Pediatric and Adolescent Gynecology, CHAM researchers have worked to develop novel curricula for directed resident education in the cross-specialty field of Pediatric and Adolescent Gynecology. A reading curriculum was published and widely distributed across Pediatric and Obstetrics and Gynecology residency training programs. Additionally, the group has published on the development and distribution process itself as it brings together educators across several fields and takes novel approaches to learning.  Furthermore, CHAM researchers have participated in prospectively testing the curriculum at both Pediatric and Obstetrics and Gynecology residency training programs. Beyond, reading assignments, CHAM researchers are working on creating and testing web-based interactive teaching modules and video simulations as well in training students, residents and fellows in PAG.

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Long-Term, Open-Label Follow-up Study of Tofacitinib for Treatment of Juvenile Idiopathic Arthritis (JIA) - Click here for more information15-10-199-01
Disease/ConditionArthritis
Autoimmune Diseases
Musculoskeletal Diseases
Pediatrics
Rheumatic Diseases
Principal InvestigatorDawn Wahezi, MD
Contact Marija Dionizovik-Dimanovski, MD

Email Contact
Trial DescriptionA Multicenter, Open-label, Randomized, Event-driven Study to Assess Efficacy, Safety and Pharmacokinetics of Macitentan Versus Standard of Care in Children With Pulmonary Arterial Hypertension (PAH) (TOMORROW) - Click here for more information16-10-366-01
Disease/ConditionHeart and Vascular Diseases
Lung Diseases
Pediatrics
Pulmonary Hypertension
Principal InvestigatorNicole Sutton, MD
Contact Chelsie Cornelius

Email Contact
Trial DescriptionA Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Subjects With Active Systemic Lupus Erythematosus - Click here for more information18-02-68-01E
Disease/ConditionAutoimmune Diseases
Dermatology
Lupus
Pediatrics
Rheumatic Diseases
Geriatrics
Principal InvestigatorChaim Putterman, MD
Contact Nicole Jordan

Email Contact
Trial DescriptionA Phase 2, Randomized, Double-Blind, Dose-Ranging Study to Determine the Pharmacokinetics, Safety and Tolerability of Vedolizumab IV in Pediatric Subjects With Ulcerative Colitis or Crohn's Disease - Click here for more information18-10-218-01
Disease/ConditionColitis and Crohn's Disease
Gastroenterology & Liver Diseases
Pediatrics
Inflammatory Bowel Disease
Principal InvestigatorJohn Thompson, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Phase 3 Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Patients w/Influenza A Infection - Click here for more information17-02-306-01
Disease/ConditionGeriatrics
Infectious Diseases
Influenza
Pediatrics
Principal InvestigatorPaul Riska, MD
Contact Bola Omotosho

Email Contact
Trial DescriptionA Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects With Moderate to Severe Atopic Dermatitis - Click here for more information18-10-220-01
Disease/ConditionDermatology
Pediatrics
Skin Disorders
Geriatrics
Immune System Diseases
Principal InvestigatorHolly Kanavy, MD
Contact Jose Jaller

Email Contact
Trial DescriptionA Phase 3, Randomized, Open-Label, Multicenter Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD) - Click here for more information18-10-59-01
Disease/ConditionHematologic Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Metabolic Diseases
Nephrology
Urologic Diseases
Pediatrics
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionA Phase II Multi-Center, Randomized, Double-Blind, 24-Week, Parallel Group, Placebo-Controlled Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Children and Adolescents Age 5-17 With Autism Spectrum Disorder (ASD) - Click here for more information16-10-117-01
Disease/ConditionAutism Spectrum Disorder
Neurodevelopmental Disorders
Pediatrics
Psychiatry - Non Cancer
Mental Health and Disorders
Principal InvestigatorEric Hollander, MD
Contact Danya Schlussel

Email Contact
Trial DescriptionA Prospective, Observational, Non-Interventional, Post-Marketing, Patient Registry to Collect Data on Routine Clinical Care in Patients Treated With Cholbam®/Kolbam® (Cholic Acid) - Click here for more information17-08-442-01
Disease/ConditionGastroenterology & Liver Diseases
Pediatrics
Liver Diseases
Principal InvestigatorNadia Ovchinsky, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Randomized, Double-Blind, Placebo-Controlled, Multi-Center Pragmatic Clinical Trial To Evaluate The Effectiveness Of Low Dose Oral Methotrexate In Patients With Pediatric Crohn's Disease Initiating Anti-TNF Therapy (COMBINE) - Click here for more information2017-7692
Disease/ConditionColitis and Crohn's Disease
Gastroenterology & Liver Diseases
Inflammatory Bowel Disease
Pediatrics
Principal InvestigatorGitit Tomer, MD
Contact Preeti Malik

Email Contact
Trial DescriptionA Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) - Click here for more information2016-6694
Disease/ConditionAnemia
Blood Disorders and Diseases
Sickle Cell
Pediatrics
Genetic Disorders
Hematologic Diseases
Principal InvestigatorCaterina Minniti, MD
Contact Andrew Crouch

Email Contact
Trial DescriptionAn Observational, Multicenter Study of the Prevalence of Cerebrotendinous Xanthomatosis (CTX) in Patient Populations Diagnosed With Early-Onset Idiopathic Bilateral Cataracts - Click here for more information15-10-432-01
Disease/ConditionGenetic Disorders
Ophthalmic Diseases and Disorders
Pediatrics
Principal InvestigatorNorman Medow, MD
Contact Jose Rosado

Email Contact
Trial DescriptionARCHIVE: A registry for children with vasculitis: e-entry 08-04-111E
Disease/ConditionHeart and Vascular Diseases
Pediatrics
Rheumatic Diseases
Autoimmune Diseases
Principal InvestigatorMaria Yee, MD
Contact Marija Dionizovik-Dimanovski

Email Contact
Trial DescriptionAssessing the Efficacy of Virtual Reality Analgesia (VRA) in Pediatric Patients for Pain Control During Botox Injections for Spasticity Management: A Randomized Control Trial - Click here for more information2016-6501
Disease/ConditionAnesthesia and Pain Management
Pediatrics
Rehabilitation Medicine
Principal InvestigatorYuxi Chen, MD
Contact Beendu Pujar

Email Contact
Trial DescriptionAutism Genetics Network, Phase II: Increasing Representation of Human Diversity 2012-537
Disease/ConditionAutism Spectrum Disorder
Neurology
Pediatrics
Genetic Disorders
Principal InvestigatorSophie Molholm, PhD
Contact Danielle DeMaio
(718) 862-1860
Email Contact
Trial DescriptionBezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001) (MODIFY III) - Click here for more information17-10-212-01
Disease/ConditionImmune System Diseases
Infectious Diseases
Pediatrics
Principal InvestigatorDavid Goldman, MD
Contact Sonia Sheehan

Email Contact
Trial DescriptionCannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD) - Click here for more information2017-8538
Disease/ConditionChild Development
Neurodevelopmental Disorders
Autism Spectrum Disorder
Principal InvestigatorEric Hollander, MD
Contact Erin Shanahan

Email Contact
Trial DescriptionChildhood Asthma Perception Study (CAPS) - Click here for more information2014-3257
Disease/ConditionAllergy & Immunology
Allergy and Immune Disorders
Asthma and other Respiratory Diseases
Pediatrics
Principal InvestigatorJonathan Feldman, PhD
Contact Jonathan Feldman, PhD

Email Contact
Trial DescriptionDefensin and Innate Mucosal Immune Mediator Expression in Pediatric Inflammatory Bowel Disease 2012-529
Disease/ConditionGastroenterology & Liver Diseases
Inflammatory Bowel Disease
Pediatrics
Principal InvestigatorGitit Tomer, MD
Contact Preeti Malik

Email Contact
Trial DescriptionEfficacy of a Gluten-free Diet in Difficult to Manage Nephrotic Syndrome: Utility of Plasma Zonulin Levels as a Predictive Biomarker - Click here for more information2017-8362
Disease/ConditionKidney Diseases (incl Chronic Kidney Disease)
Nephrology
Pediatrics
Urologic Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionHydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial - Click here for more information2017-8570
Disease/ConditionAnemia
Hematologic Diseases
Pediatric Hematology/Oncology
Pediatrics
Genetic Disorders
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland

Email Contact
Trial DescriptionMolecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction - Click here for more information2018-8749
Disease/ConditionNeonatology
Pediatrics
Overweight, Obesity and Weight Loss
Principal InvestigatorMamta Fuloria, MD
Contact Sonia Sheehan

Email Contact
Trial DescriptionMulticenter, Open Label, Phase 3 Study of Tabelecleucel for Solid Organ Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE) - Click here for more information16-10-296-01
Disease/ConditionEpstein-Barr Virus (EBV)
Lymphoproliferative Disorders
Pediatric Hematology/Oncology
Pediatrics
Solid Organ Transplant (SOT) Complications
Immune System Diseases
Principal InvestigatorDavid Loeb, MD
Contact Elodie Benard

Email Contact
Trial DescriptionNephrotic Syndrome Study Network Under the Rare Diseases Clinical Research Network (NEPTUNE) - Click here for more information09-06-182
Disease/ConditionGeriatrics
Kidney Diseases (incl Chronic Kidney Disease)
Nephrotic Syndrome
Pediatrics
Urologic Diseases
Immune System Diseases
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn

Email Contact
Trial DescriptionPeer Mentor Training to Reduce Hospitalizations for Children With Asthma - Click here for more information10-06-174E
Disease/ConditionLung Diseases
Pediatrics
Asthma and other Respiratory Diseases
Principal InvestigatorDeepa Rastogi, MD
Contact Deepa Rastogi, MD

Email Contact
Trial DescriptionPhase 2 Study: Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Children and Adolescents With Prader-Willi Syndrome - Click here for more information2017-8076
Disease/ConditionPsychiatry - Non Cancer
Nervous System Diseases
Child Development
Pediatrics
Genetic Disorders
Principal InvestigatorEric Hollander, MD
Contact Danya Schlussel

Email Contact
Trial DescriptionPhase III Multicenter Open-label Randomized Clinical Trial Comparing Everolimus and Low Dose Tacrolimus to Tacrolimus and Mycophenolate Mofetil at 6 mo Post-Transplant to Prevent Long-term Complications After Pediatric Heart Transplantation - Click here for more information2017-8626
Disease/ConditionHeart and Vascular Diseases
Kidney Diseases (incl Chronic Kidney Disease)
Pediatrics
Urologic Diseases
Cardiovascular and Thoracic Surgery
Principal InvestigatorJacqueline Lamour, MD
Contact Helen Alexander

Email Contact
Trial DescriptionPromoting Asthma Guidelines and Management through Technology-Based Intervention and Care Coordination (PRAGMATIC) - Click here for more information2016-6258
Disease/ConditionAsthma and other Respiratory Diseases
Pediatrics
Lung Diseases
Principal InvestigatorMarina Reznik, MD
Contact Guadalupe Salazar

Email Contact
Trial DescriptionProtocol for a Research Sample Repository and for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies, and Marrow Toxic Injuries - Click here for more information2015-5698
Disease/ConditionHematologic Diseases
Neoplasms
Pediatric Hematology/Oncology
Pediatrics
Oncology (Medical/Hematologic)
Principal InvestigatorDavid Loeb, MD
Contact Marissa Green

Email Contact
Trial DescriptionSelf regulation in children with learning disabilities and inattention/hyperactivity IRB# 2006-425
Disease/ConditionChild Development
Principal InvestigatorKatherine Lawson, PhD
Contact Maria Valicenti-McDermott, MD
(718) 430-8600 6275
Email Contact
Trial DescriptionSimple Bone Cysts in Kids (SBoCK) - Click here for more information2015-4768
Disease/ConditionBones, Muscles & Joints (Orthopaedics)
Orthopaedic Surgery
Pediatrics
Neoplasms
Musculoskeletal Diseases
Principal InvestigatorJacob Schulz, MD
Contact Regina Hanstein

Email Contact
Trial DescriptionStudy of Allogeneic EBV-CTLs in EBV-Associated Viremia or Malignancies - Click here for more information16-10-116-01
Disease/ConditionHematologic Diseases
Pediatrics
Principal InvestigatorDavid Loeb, MD
Contact Elodie Benard

Email Contact
Trial DescriptionVALENS: A Ph 1/2, Random'd, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate Safety/Preliminary Efficacy of AT342, an AAV8-Delivered Gene Transfer Therapy in Crigler-Najjar Syndrome Subjects Aged 1 Yr and Older - Click here for more information2017-7918
Disease/ConditionBrain and Neurological
Crigler-Najjar Syndrome
Gastroenterology & Liver Diseases
Heart and Vascular Diseases
Metabolic Diseases
Pediatrics
Principal InvestigatorNadia Ovchinsky, MD
Contact Sharon Thomas

Email Contact
Trial DescriptionWeb-based Peer Mentor Training to Reduce Hospitalizations for Children with Asthma - Click here for more information2014-3962
Disease/ConditionAsthma and other Respiratory Diseases
Pediatrics
Lung Diseases
Principal InvestigatorDeepa Rastogi, MD
Contact Toni Tobias

Email Contact
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