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Research

Contact Critical Care Medicine at CHAM

In addition to our award-winning staff, our emphasis on technological advances places us among the finest critical care units in the region. Over the years, our excellent clinical care has been complemented by our ongoing research efforts in numerous areas—including BiPAP, inhaled nitric oxide and noninvasive mechanical ventilation—as well as the numerous clinical studies we conduct to advance pediatric critical care medicine. In addition, we encourage the fellows in our division to participate in mentored research in both the laboratory and clinical studies.

We are currently conducting research in the following areas:

  • The PPE Protocol Development with National Institute of Child Health and Human Development (NICHD) study tests the ability of responders to perform basic and advanced pediatric resuscitation procedures while wearing different classes of personal protective equipment (PPE).

  • The Pediatric ICU Surge Capacity group works with the New York City Department of Health and Mental Hygiene (DOHMH) and the New York City Pediatric Disaster Coalition (NYCPDC) to improve the ability of CHAM and other hospitals in the city to manage a large influx of critically ill children in the event of a natural or manmade disaster. Our group designs and tests functional  pediatric ICU (PICU) surge capacity plans. Our group has already designed and carried out a full-scale PICU surge drill.

  • Differences between the composition of breast milk and the relation to susceptibility to necrotizing enterocolitis, or NEC, a disease that primarily affects premature infants. Specifically, the milk is evaluated for several pro and anti-inflammatory cytokines involved in the pathogenesis of NEC, and methods to alter cytokine signaling and downstream effects are studied to determine possible avenues for prevention.

  • The use of lactadherin in the treatment of systemic inflammatory response syndrome (SIRS), a physiologic stress response to insults such as severe trauma, burns, ischemia or surgery.  Lactadherin—a completely novel approach to SIRS with the potential for lifesaving intervention—is a molecule that is normally released by immune cells, attaches to dying cells, tags them for clearance by phagocytosis and thereby attenuates inflammation. 

  • The potential detrimental effects of oxygen on the respiratory dynamics of pediatric patients outside of the neonatal intensive care unit with exacerbation of asthma. 

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Multicenter Study to Obtain Retrospective Data for Subjects Previously Diagnosed With Adenovirus Infection to Serve as Matched Historical Controls for Study CMX001-304 - Click here for more informationIRB# 15-10-122
Disease/ConditionInfectious Disease
Principal InvestigatorKris Mahadeo, MD
Contact Ruth Santizo
(718) 741-2287
Email Contact
Trial DescriptionA Safety Extension Study to Evaluate the Safety and Tolerability of Benralizumab (MEDI-563) in Asthmatic Adults and Adolescents on Inhaled Corticosteroid Plus LABA (BORA) - Click here for more informationIRB# 15-02-209
Disease/ConditionAsthma and other Respiratory Diseases
Principal InvestigatorGolda Hudes, MD
Contact Mydalyn Beronilla
(718) 405-8075
Email Contact
Trial DescriptionAcute Kidney Injury in Children with Acute Respiratory Failure IRB# 2014-3464
Disease/ConditionKidney Disease and Transplant
Asthma and other Respiratory Diseases
Principal InvestigatorScott Aydin, MD
Contact Scott Aydin, MD
(718) 741-2343
Email Contact
Trial DescriptionAn Observational Study of Respiratory Syncytial Virus (RSV) Hospitalizations in Preterm Infants (SENTINEL1) - Click here for more informationOCT14-0608B; IRB# 14-10-456-01
Disease/ConditionInfant Care
Infectious Disease
Principal InvestigatorIona Munjal, MD
Contact Sonia Sheehan
(718) 741-2478
Email Contact
Trial DescriptionAzithromycin for Children Hospitalized With Asthma - Click here for more informationIRB# 12-05-187
Disease/ConditionAsthma and other Respiratory Diseases
Principal InvestigatorLindsey Douglas, MD
Contact Lindsey Douglas, MD
(718) 741-2267
Email Contact
Trial DescriptionEPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures (EPVent2) - Click here for more informationIRB# 2012-268
Disease/ConditionCritical Care
Asthma and other Respiratory Diseases
Principal InvestigatorMichelle Gong, MD
Contact Daniel Ceusters
(718) 920-2956
Email Contact
Trial DescriptionHeart And Lung Failure - Pediatric INsulin Titration Trial (HALF-PINT) - Click here for more informationIRB# 2013-386-001
Disease/ConditionPediatric Critical Care
Principal InvestigatorShivanand Medar, MD
Contact Shivanand Medar, MD
(718) 741-2491
Email Contact
Trial DescriptionImproving Pediatric Transport to the Children's Hospital at Montefiore IRB# 2014-4034
Disease/ConditionPediatric Critical Care
Principal InvestigatorChhavi Katyal, MD
Contact Chhavi Katyal, MD
(718) 741-2476
Email Contact
Trial DescriptionIntravenous Gammaglobulin for Sickle Cell Pain Crises - Click here for more informationIRB # 09-06-172
Disease/ConditionBlood Disorders and Diseases
Anesthesia and Pain
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland
(718) 741-2401
Email Contact
Trial DescriptionRetrospective Evaluation of Sedation Efficacy for Magnetic Resonance Imaging in Pediatric Patients: Dexmedetomidine versus Propofol. IRB# 2013-2541
Disease/ConditionAnesthesia and Pain
Principal InvestigatorChhavi Katyal, MD
Contact Chhavi Katyal, MD
(718) 741-2476
Email Contact
Trial DescriptionStudy of Tedizolid Phosphate (TZD) in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012) - Click here for more informationIRB# 14-10-524Q
Disease/ConditionInfectious Disease
Skin Disorders
Principal InvestigatorIona Munjal, MD
Contact Sonia Sheehan
(718) 741-2470
Email Contact
Trial DescriptionThe National Emergency Airway Registry for Children IRB# 2014-3877
Disease/ConditionAsthma and other Respiratory Diseases
Principal InvestigatorMichael Miksa, MD
Contact Michael Miksa, MD
(718) 741-2455
Email Contact
View all Clinical Trials