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Hematology, Oncology and Marrow and Blood Cell Transplantation

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Research

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We are devoted to providing the very best care and treatment for the children and adolescents with cancer and blood disorders. To do so, we adopt the newest and most effective treatments currently available while we work continuously and actively towards innovations and improvements. As a result, we have established ourselves as a force of excellence at the forefront of clinical research and development in the field of childhood cancer and blood disorders.



Providing access to clinical trials worldwide

As a vital element of our comprehensive, child-centered approach, CHAM offers our patients access to the latest, most promising clinical trials. New treatments for childhood cancer and blood disorders are being developed constantly, and clinical trials allow our patients to be among the first to try pioneering treatment agents and concepts.

CHAM is an active member of the Children’s Oncology Group (COG), an international consortium of pediatric cancer centers dedicated to advancing treatment for children with cancer by combining global resources and expertise for clinical trials. Our patients benefit from access to all the latest national and international trials, through CHAM, COG and the National Institutes of Health.

We participate in the Dana Farber Cancer Institute’s Acute Lymphoblastic Leukemia Consortium, with access to their clinical trials. We also participate in industry-sponsored and NIH-supported investigator-initiated clinical trials

Bringing research from the laboratory to the bedside

At CHAM, we are dedicated to actively pursuing new areas of research right here at Montefiore by developing our own treatment agents and therapies. We confront highly aggressive forms of pediatric cancer and blood disease with an equally aggressive push toward advancing the field of research and development. Our passionate, proactive approach includes pioneering our own agents and treatment concepts that can be tested in clinical trials.

Leading the fight against childhood disease

Among other areas of clinical research, CHAM is currently involved in cutting-edge clinical trials for our patients with leukemia, focusing specifically on reducing the toxic side effects of curative therapy. In pediatric neuro-oncology, we have developed innovative monitoring equipment and are working on software that will increase the safety and accuracy of the very delicate surgery required to treat brain tumors.We are currently focused on a new trial of chemotherapy for a rare form of brain tumor (ATRT).

We have gained a national reputation as a groundbreaking center of study on sickle cell disease. CHAM has participated in stroke prevention trials and has participated in efforts to test the efficacy of hydroxyurea. In addition, we have been awarded an NIH grant to study the role of genetics, screening sickle cell patients for risk of stroke.

In all areas of applicable research, CHAM is a key player in the ultimate fight — to one day eradicate childhood cancer and blood disease entirely.

Below is a listing of current clinical trials in Childhood Cancers and Blood Disorders


Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionChemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma - Click here for more informationIRB# 08-03-057
Disease/ConditionBrain Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionChemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors - Click here for more informationIRB# 12-08-281
Disease/ConditionBrain Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Biological Samples From Patients With Ewing Sarcoma - Click here for more informationIRB# 08-09-335
Disease/ConditionBone Cancer
Principal InvestigatorPeter Cole, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma - Click here for more informationIRB# 08-09-336E
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Tissue From Young Patients With Cancer - Click here for more informationABTR04B1
Disease/ConditionCancer and Genetics
Principal InvestigatorPeter Cole, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCollecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma - Click here for more informationIRB# 1199905158
Disease/ConditionSoft Tissue Sarcoma/Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionCombination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-Metastatic Desmoplastic Medulloblastoma - Click here for more informationIRB# 2015-4856
Disease/ConditionBrain Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionDenosumab in Treating Patients With Recurrent or Refractory Osteosarcoma - Click here for more informationIRB# AOST1321
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionDinutuximab in Combination With Sargramostim in Treating Patients With Recurrent Osteosarcoma - Click here for more informationIRB# AOST1421
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionGlembatumumab Vedotin in Treating Patients With Recurrent or Refractory Osteosarcoma - Click here for more informationIRB# AOST1521
Disease/ConditionBone Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionInternational Registry for Severe Chronic Neutropenia - Click here for more informationIRB# 03-01-015E
Disease/ConditionBlood Disorders and Diseases
Principal InvestigatorKerry Morrone, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionIntravenous Gammaglobulin for Sickle Cell Pain Crises - Click here for more informationIRB # 09-06-172
Disease/ConditionBlood Disorders and Diseases
Anesthesia and Pain
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland
(718) 741-2401
Email Contact
Trial DescriptionMetformin in Children With Relapsed or Refractory Solid Tumors - Click here for more informationIRB# 12-05-190
Disease/ConditionSolid Tumor
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionProfiling Actionable Genetic Alterations in Pediatric Tumors: The Children's Hospital at Montefiore Protocol for Screening Pediatric Tumors to Define Genetic Alterations IRB# 2014-3436
Disease/ConditionCancer and Genetics
Principal InvestigatorAdam Levy, MD
Contact Janeta Ivanova
(718) 741-2356
Email Contact
Trial DescriptionProject: Every Child for Younger Patients With Cancer - Click here for more informationIRB# 2016-5989
Disease/ConditionCancer and Genetics
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionProphylactic Antibiotic Regimens in Tumor Surgery (PARITY) - Click here for more informationIRB# 2014-4077
Disease/ConditionBone Cancer
Principal InvestigatorDavid Geller, MD
Contact Janet Tingling

Email Contact
Trial DescriptionRadiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery (PAZNTIS) - Click here for more informationIRB# 2015-4866
Disease/ConditionSoft Tissue Sarcoma/Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2338
Email Contact
Trial DescriptionRisk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer - Click here for more informationIRB# 10-04-087
Disease/ConditionLiver Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionStudy of Kidney Tumors in Young Patients - Click here for more informationIRB# 08-05-181E
Disease/ConditionKidney Cancer
Principal InvestigatorJonathan Gill, MD
Contact Joyce Brown
(718) 741-2356
Email Contact
Trial DescriptionStudy to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload - Click here for more informationIRB# 15-02-284
Disease/ConditionBlood Disorders and Diseases
Principal InvestigatorDeepa Manwani, MD
Contact Karen Ireland
(718) 741-2401
Email Contact
View all Clinical Trials