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The depth and breadth of expertise within the Division of Neurosurgery spans the clinical spectrum of problems affecting children’s brains, spinal cords and nerves.

Our unique team approach to managing challenging neurological problems has improved outcomes, reduced the number of surgeries that children require and allowed patients’ advanced access to innovative treatments.

Innovation is at the heart of all we do. Our division, for instance, was among the first to use cranial vault reconstruction (CVR) to reshape the head and among the first to modify and use CVR techniques for mid-face reconstructions following trauma or tumor resection.

We are currently focused on research to:

Evaluate Hydrocephalus-Linked Headaches Using Magnetic Resonance Elastography

Our division is pioneering new diagnostic options for hydrocephalic children with chronic headaches. By implanting a pressure sensor and conducting ICU-based monitoring, we can assess potential correlations between headaches and intracranial pressure. In collaboration with radiologists, we are also developing a groundbreaking magnetic resonance elastography technique that noninvasively gauges whether brain tissue elasticity decreases due to shunting.

Provide New Treatment Options for Children and Adults with Chronic Disabilities

Focal hypertonicity accompanying conditions such as cerebral palsy, spina bifida and stroke can freeze joints and severely impede normal movement. Injection-based denervation therapies offer only temporary relief or weaken muscles. We are seeing promising initial results using an alternative method of selectively cutting only problematic nerve fibers thereby resolving abnormal spasticity and other forms of hypertonicity while preserving muscle strength and function.

Trial Description
Disease / Condition
Principal Investigator
Trial DescriptionA 12-Month, Open-Label, Repeat-Dose Safety Study of NRL-1 in Epilepsy Subjects - Click here for more information16-10-27-01
Brain and Neurological
Principal InvestigatorAlexis Boro, MD
Contact Jeanne Gutierrez

Email Contact
Trial DescriptionAutism Genetics Network, Phase II: Increasing Representation of Human Diversity 2012-537
Disease/ConditionAutism Spectrum Disorder
Genetic Disorders
Principal InvestigatorSophie Molholm, PhD
Contact Danielle DeMaio
(718) 862-1860
Email Contact
Trial DescriptionInfantile Spasms Multicenter Database IRB# 13-01-027
Disease/ConditionBrain and Neurological
Principal InvestigatorElissa Yozawitz, MD
Contact Elissa Yozawitz, MD
(718) 920-4378
Email Contact
Trial DescriptionMaintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma - Click here for more information10-07-196
Disease/ConditionBrain and Neurological
Principal InvestigatorLisa Gennarini, MD
Contact Joyce Brown

Email Contact
Trial DescriptionThe use of Virtual Reality Games to Enhance Therapy for Children with Cerebral Palsy. A pilot Study IRB# 2008-347
Disease/ConditionBrain and Neurological
Principal InvestigatorMaria Valicenti-McDermott, MD
Contact Maria Valicenti-McDermott, MD
(718) 430-8600 Ext 6275
Email Contact
Trial DescriptionVALENS: A Ph 1/2, Random'd, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate Safety/Preliminary Efficacy of AT342, an AAV8-Delivered Gene Transfer Therapy in Crigler-Najjar Syndrome Subjects Aged 1 Yr and Older - Click here for more information2017-7918
Disease/ConditionBrain and Neurological
Crigler-Najjar Syndrome
Gastroenterology & Liver Diseases
Heart and Vascular Diseases
Metabolic Diseases
Principal InvestigatorNadia Ovchinsky, MD
Contact Sharon Thomas

Email Contact
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