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Research

Our basic, clinical and translational research is aimed at identifying the major problems affecting children from birth throughout the life-course and into transition to adult care including: 

  • Disorders of abnormal kidney and genitourinary tract development

  • Genetics of inherited kidney abnormalities and predisposition to chronic kidney injury

  • Acquired kidney conditions including the nephrotic syndrome of childhood, immune-mediated disorders, high blood pressure and progressive kidney failure in the transplanted organ


  • We participate in the NIH-funded collaborative clinical trials to better understand chronic kidney disease, its prevention, and more effective treatment in children including:
     
    Standardized Care to Improve Outcomes in Pediatric End-Stage Renal Disease (SCOPE)

    Our pediatric dialysis center is an active member of the SCOPE collaborative, a multicenter performance improvement workgroup focused on reducing the rates of exit-site infections and peritonitis for children receiving chronic peritoneal dialysis. Through this network, CHAM patients have seen a 27 percent reduction in peritonitis rates already.
     
    Understanding Focal Glomerulosclerosis

    We are examining the role of Par1a/b in establishing and maintaining podocyte structure and de­fining polarity protein expression in human nephrotic syndrome and glomerulosclerosis. The team is hoping to identify new targets for therapeutic intervention and biomarkers for progressive kidney disease, and anticipates these discoveries will allow for early detection and early intervention as well as better treatments for focal glomerulosclerosis. In addition, we are involved in a collaboration examining the important risk cardiovascular alleles APOL 1 and 2 in African Americans born prematurely.
     
    Better Diagnosis and Tailored Treatments for Lupus Nephritis

    We are studying the role of microRNAs in the development and progression of lupus nephritis, their detection in human urine samples, and their role as biomarkers of active disease. We hope to find biomarkers that can both diagnose and measure disease, which may lead to tailored treatments rather than the current use of immunosuppressant drugs that target the whole kidney and can cause unwanted side effects.
     
    The Nephrotic Syndrome Rare Disease Clinical Research Network and Cure Glomerulonephropathy

    A collaboration conducting clinical and translational research in the major causes of glomerular diseases in children and adults.
     
    The Chronic Kidney Disease in Children Cohort

    A collaboration aimed at determining the risk factors for progressive kidney failure in infants and children and its effects on neurocognition, cardiovascular disease and growth and development.
     
    Group Based Kidney Care

    An innovative study to develop more effective means of improving patient education and adherence to the treatment of hypertension and chronic kidney disease.
     

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Multicenter Single-arm Extension Study to Characterize the Long-term Safety of Cinacalcet Hydrochloride in the Treatment of Secondary Hyperparathyroidism in Pediatric Subjects With Chronic Kidney Disease on Dialysis - Click here for more informationIRB# 20140159
Disease/ConditionDiabetes and Endocrine
Kidney Disease and Transplant
Principal InvestigatorAnna Zolotnitskaya, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionACTH for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome - Click here for more informationIRB# 2014-3512
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorKimberly Reidy, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionAcute Kidney Injury in Children with Acute Respiratory Failure IRB# 2014-3464
Disease/ConditionKidney Disease and Transplant
Asthma and other Respiratory Diseases
Principal InvestigatorScott Aydin, MD
Contact Scott Aydin, MD
(718) 741-2343
Email Contact
Trial DescriptionAtypcial Hemolytic-Uremic Syndrome (aHUS) Registry - Click here for more informationOCT12-0278; IRB# 12-12-417
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorFrederick Kaskel, MD
Contact Patricia Flynn
(718) 655-1120
Email Contact
Trial DescriptionCureGN: Cure Glomerulonephropathy Network IRB# 2014-4254
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorFrederick Kaskel, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionNephrotic Syndrome Study Network (NEPTUNE) - Click here for more informationIRB# 2013-272
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorFrederick Kaskel, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionNorth American Pediatric Renal Trials and Collaborative Studies IRB# 02-06-151E
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorMarcela Del Rio, MD
Contact Patti Flynn
(718) 655-1120
Email Contact
Trial DescriptionOutcomes of Neonatal Acute Kidney Injury In Premature Infants - Click here for more informationIRB# 2013-2900
Disease/ConditionKidney Disease and Transplant
Principal InvestigatorMamta Fuloria, MD
Contact Mamta Fuloria, MD
(718) 904-4105
Email Contact
View all Clinical Trials